Prescription Drug Withdrawal

The most commonly associated prescription drugs with withdrawal include opioid painkillers (such as oxycodone, hydrocodone, and codeine), benzodiazepines (like Xanax, Valium, and Ativan), and certain sleep medications and stimulants. These medications can create physical dependence relatively quickly, meaning your body adapts to their presence and struggles to function without them.

If you or someone you love is facing prescription drug withdrawal, understanding what to expect—and knowing that help is available—can make all the difference in navigating this difficult but necessary step toward recovery.

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What Are the Withdrawal Symptoms of Prescription Drugs?

Withdrawal symptoms vary depending on the type of medication, how long you’ve been taking it, and your individual physiology. However, there are common patterns associated with different drug classes.

Opioid withdrawal, while rarely life-threatening, is often described as intensely uncomfortable. Symptoms typically include muscle aches, sweating, anxiety, agitation, insomnia, nausea, vomiting, diarrhea, and intense cravings. Many people describe it as resembling a severe case of the flu, with overwhelming restlessness. The discomfort can be so significant that many people return to using it just to find relief, which is why professional support is so valuable.

Benzodiazepine withdrawal can be more medically serious and should always be monitored by healthcare professionals.

Symptoms may include anxiety, panic attacks, tremors, sweating, difficulty concentrating, sleep disturbances, irritability, and, in severe cases, seizures. 

Because benzodiazepines affect the brain’s GABA receptors, stopping them abruptly can cause the nervous system to become overactive, which is why a gradual tapering approach is typically recommended.

Stimulant withdrawal (from medications like Adderall or Ritalin) often presents differently, with symptoms such as fatigue, depression, increased appetite, sleep disturbances, and difficulty experiencing pleasure. While physically less dangerous, the psychological symptoms can be difficult to manage alone.

Regardless of the substance, withdrawal is your body’s way of readjusting to functioning without the drug. It’s a sign that healing is beginning—even when it might not feel that way.

How Long Do Withdrawal Symptoms Last?

While there’s no one-size-fits-all answer, there are a few general timelines. Exact timelines, however, can vary.

For opioids, acute withdrawal symptoms typically begin within eight to 24 hours after the last dose and peak around 36 to 72 hours. Most physical symptoms subside within a week, though some people experience lingering effects like fatigue, sleep issues, and cravings for several weeks or even months.

Benzodiazepine withdrawal follows a different pattern and depends heavily on whether you were taking a short-acting or long-acting medication. Symptoms may begin within 24 hours with short-acting benzodiazepines or may take several days to appear with long-acting benzodiazepines. The acute phase can last anywhere from a few weeks to several months, and some individuals experience protracted withdrawal symptoms that persist for much longer. This is why medical supervision and a slow taper are so important.

Stimulant withdrawal is generally shorter, with the most intense symptoms occurring in the first week and gradually improving over the following weeks. However, depression and fatigue can linger for a month or more in some cases.

It’s important to remember that these timelines are general guides. Your experience may be shorter or longer, and factors such as your overall health, duration of use, and whether you have support can all influence your recovery.

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How to Deal With Prescription Drug Withdrawal

Facing withdrawal can feel daunting, but you don’t have to white-knuckle your way through it alone. There are effective strategies and resources that can help make the process safer and more manageable, including the following.

Seek Out Medical Guidance

The first and most important step is to talk to a licensed healthcare professional before stopping any prescription medication. Quitting cold turkey can be dangerous, especially with benzodiazepines and certain other drugs. 

A doctor, however, can help you create a tapering schedule that gradually reduces your dose, minimizing withdrawal symptoms and reducing health risks. In some cases, medication-assisted treatment can help ease symptoms and reduce cravings.

Consider Professional Detox

For many people, a supervised detox program offers the safest and most comfortable path through withdrawal. Medical professionals can monitor your symptoms around the clock, provide medications to alleviate discomfort, and intervene promptly if complications arise. This is especially important for benzodiazepine withdrawal, where seizures are a real concern, or for anyone with underlying health conditions.

Build a Support System

Withdrawal is physically and emotionally exhausting. Having people you can lean on—whether friends, family, or support group members—can make a significant difference. Don’t be afraid to ask for help, whether that means someone to talk to during a difficult moment or practical support like help with meals or childcare.

Focus on Self-Care

While it may be the last thing on your mind, taking care of your basic needs can help your body heal. Stay hydrated, eat nutritious foods when you can, and rest as much as possible. Gentle movement, such as short walks, can help with restlessness and boost mood. Avoid caffeine and other stimulants that might increase anxiety.

Prepare for the Emotional Side of Things

Withdrawal isn’t just physical. Many people experience mood swings, anxiety, depression, and irritability during this time. These feelings are normal and temporary, but they can be intense.

Thus, having coping strategies in place—like deep breathing, mindfulness, journaling, or simply having someone to call—can help you ride out the difficult moments.

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Getting the Help You Need

The Freedom Recovery Centers (FRC) team is here to support you through every step of the process. We understand how overwhelming it can feel to realize you’ve become dependent on a medication—especially one that was supposed to help you. There’s no shame in needing support, and seeking help is a sign of strength.

Our compassionate team provides medically supervised detox, personalized treatment plans, and ongoing support to help you not only get through withdrawal but build a foundation for lasting recovery. We’ll meet you where you are and walk alongside you toward a healthier, freer life. Call us today at 804-635-3746. Recovery is possible, and it starts with one phone call.